When should you not use abciximab?
Contraindications
- Hypersensitivity to abciximab or component of the formulation.
- Recent (within six weeks) clinically significant gastrointestinal (GI) or genitourinary (GU) bleeding or active internal hemorrhage.
- Within two years of cerebrovascular accident or with substantial neurological deficit.
What type of drug is abciximab?
Abciximab is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.
What is abciximab used for?
ReoPro® (abciximab) is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications: in patients undergoing percutaneous coronary intervention.
Is abciximab an anticoagulant?
It is a glycoprotein IIb/IIIa inhibitor. While abciximab has a short plasma half-life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks….Abciximab.
| Monoclonal antibody | |
|---|---|
| Source | Chimeric (mouse/human) |
| Target | CD41 7E3 |
| Clinical data | |
| Trade names | Reopro |
Can abciximab cause thrombocytopenia?
Profound abciximab induced thrombocytopenia has an incidence of 8.5%. It occurs rapidly after drug infusion (within 2–4 h); upon discontinuation of abciximab, platelet values return to normal in 2–5 days, but may be prolonged past 10 days.
Is abciximab still available?
Janssen will no longer have Reopro in the US. The last lot expires September 2019.
What is bivalirudin made from?
Bivalirudin (Bivalitroban), sold under the brand names Angiomax and Angiox and manufactured by The Medicines Company, is a direct thrombin inhibitor (DTI). Chemically, it is a synthetic congener of the naturally occurring drug hirudin, found in the saliva of the medicinal leech Hirudo medicinalis.
Why is abciximab no longer available?
Supplies of abciximab (ReoPro; Janssen Pharmaceuticals) are running low or have dried up altogether, following a manufacturing snafu affecting stocks of the glycoprotein IIb/IIIa Inhibitor around the globe.
How does abciximab cause Pseudothrombocytopenia?
Once HIT is excluded, it is also important to exclude pseudothrombocytopenia, which is specific to abciximab. Pseudothrombocytopenia is caused by platelet clumping, causing a falsely decreased platelet level.
What class drug is bivalirudin?
Bivalirudin is a medication used to manage and treat patients undergoing percutaneous coronary intervention for acute myocardial infarction. It is in the direct thrombin inhibitor class of drugs.
Is bivalirudin approved for hit?
Bivalirudin is the most recent direct thrombin inhibitor to be introduced to the market, but it is not currently FDA approved for HIT.
Does bivalirudin cause thrombocytopenia?
The incidence of major bleeding was lower in the bivalirudin group than in the heparin group….Bleeding.
| Bivalirudin with “provisional” GPI1 (n=2,914) | Heparin + GPI (n=2,987) | |
|---|---|---|
| Access site bleeding | ||
| – Sheath site bleeding | 0.9% | 2.4% |
| Thrombocytopenia5 | ||
| <100,000 | 0.7% | 1.7% |