What is the generic name for CUROSURF?
CUROSURF (poractant alfa) is a sterile, non-pyrogenic pulmonary surfactant intended for intratracheal use only.
What type of drug is Calfactant?
Infasurf® (calfactant) Intratracheal Suspension is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation only. It is an extract of natural surfactant from calf lungs which includes phospholipids, neutral lipids, and hydrophobic surfactant-associated proteins B and C (SP-B and SP-C).
What is CUROSURF used for?
Curosurf is used to treat or prevent Respiratory Distress Syndrome (RDS) in newborn babies. Most babies are born with a substance in their lungs known as ‘surfactant’.
How much does CUROSURF cost?
The cost for Curosurf intratracheal suspension (80 mg/mL) is around $525 for a supply of 1.5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is CUROSURF made from?
CUROSURF is a natural surfactant, prepared from porcine lungs, containing almost exclusively polar lipids, in particular phosphatidylcholine (about 70% of the total phospholipid content), and about 1% of specific low molecular weight hydrophobic proteins SP-B and SP-C.
When do you administer CUROSURF?
The initial recommended dose of CUROSURF is 2.5 mL/kg birth weight. Up to 2 repeat doses of 1.25 mL/kg birth weight each may be administered at approximately 12‑hour intervals. A total of 4 doses of Survanta (4 mL/kg birth weight) can be administered no more frequently than every 6 hours in the first 48 hours of life.
How is calfactant administered?
Calfactant is given directly into the baby’s lungs through a breathing tube that is also connected to a ventilator (a machine that moves air in and out of the lungs to help your baby breathe easier and get enough oxygen). Your baby will remain under constant supervision during treatment with calfactant.
What is the role of surfactant in alveoli?
Surfactant is released from the lung cells and spreads across the tissue that surrounds alveoli. This substance lowers surface tension, which keeps the alveoli from collapsing after exhalation and makes breathing easy.
Can CUROSURF cause a pulmonary hemorrhage?
Pulmonary hemorrhage, a known complication of premature birth and very low birth-weight, has been reported both in clinical trials with CUROSURF and in postmarketing adverse event reports in infants who had received CUROSURF.
How often can you give CUROSURF?
How does CUROSURF work?
CUROSURF is a natural surfactant obtained from pigs which works in the same way as human surfactant. It will therefore help your baby to breathe normally until your baby produces their own surfactant.
What kind of surfactant is Curosurf used for?
CUROSURF (poractant alfa) is a sterile, non-pyrogenic pulmonary surfactant intended for intratracheal use only. CUROSURF is an extract of natural porcinelung surfactant consisting of 99% polar lipids (mainly phospholipids) and 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C).
How much Poractant is in a vial of Curosurf?
CUROSURF (poractant alfa) is an intratracheal suspension available in vials: 3 mL [240 mg poractant alfa (surfactant extract)]. CUROSURF is a white to creamy white suspension.
How is Calfactant used to treat respiratory distress syndrome?
Calfactant is a lung surfactant for the prophylaxis of respiratory distress syndrome in high-risk infants. Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline.
How is Curosurf used to treat respiratory distress syndrome?
CUROSURF® (poractant alfa) Intratracheal Suspension is indicated for the rescue treatment of Respiratory Distress Syndrome (RDS) in premature infants. CUROSURF reduces mortality and pneumothoraces associated with RDS.