What is the difference between COX-1 and COX-2 inhibitors?
In the gastrointestinal tract, COX-1 maintains the normal lining of the stomach and intestines, protecting the stomach from the digestive juices. 4 The enzyme is also involved in kidney and platelet function. COX-2, on the other hand, is primarily found at sites of inflammation.
Are NSAIDs COX-1 and COX-2 inhibitors?
NSAIDs inhibit the rate-limiting enzyme cyclooxygenase (COX) in prostaglandin synthesis and two COX isoforms have been identified, COX-1 and COX-2. The COX-1 isoform produces cytoprotective prostaglandins and is present in most tissues, including the gastrointestinal mucosa, kidneys, and platelets.
Is aspirin a COX-1 inhibitor?
There are at least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2). Aspirin is non-selective and irreversibly inhibits both forms (but is weakly more selective for COX-1).
Is naproxen a COX-1 or COX-2 inhibitor?
Naproxen is a non-steroidal, antiinflammatory agent. It is a non-selective COX-1 and COX-2 inhibitor Mitchell et al (1993).
What is COX-1 responsible for?
COX-1 appears to be responsible for the production of prostaglandins (PG) that are important for homeostatic functions, such as maintaining the integrity of the gastric mucosa, mediating normal platelet function, and regulating renal blood flow.
Is Voltaren a Cox-2 inhibitor?
The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Is ibuprofen a COX-1 or 2 inhibitor?
The main mechanism of action of ibuprofen is the non-selective, reversible inhibition of the cyclooxygenase enzymes COX-1 and COX-2 (coded for by PTGS1 and PTGS2, respectively).
What does COX-1 do in the stomach?
The COX-1–derived prostaglandins are responsible for gastric mucosal protection through vasodilation, stimulation, and secretion of gastroduodenal mucus and bicarbonate, and forming a protective barrier to acid injury.
What do COX inhibitors do?
COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever.
What are the different types of COX inhibitors?
Valdecoxib, rofecoxib, and celecoxib are the three types of COX inhibitors that affect only COX-2.
What is the difference between Cox 1 and 2?
Difference in Locations: COX-1 is commonly found in the kidney, stomach and platelets whereas COX-2 is located in macrophages, leukocytes and fibroblasts.
What is selective COX inhibitor?
Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain.
What does Cox 1 do?
In the gastrointestinal tract, COX-1 maintains the normal lining of the stomach and intestines, protecting the stomach from the digestive juices. The enzyme is also involved in kidney and platelet function.