What is receptor gamma?
Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.
What genes does estrogen activate?
Several genes that are induced by estrogens in MCF-7 cells are activated through one or more GC-rich sites in their regulatory regions and these include the cathepsin D, E2F1, bcl-2, c-fos, adenosine deaminase, insulinlike growth factor binding protein 4, and retinoic acid receptor alpha 1 genes.
How does estrogen activate gene expression?
Estrogen hormones regulate gene expression. They achieve this by first binding to estrogen receptor in the cell nucleus, which triggers the recruitment of different molecules called coactivators in specific order. After estrogen binds to its receptor, different coactivators bind to the complex in a sequential manner.
Where are PPAR gamma receptors?
PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues except muscle) and PPAR-γ2 (mostly found in adipose tissue and the intestine).
What type of receptor is estrogen receptor?
Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol)….Estrogen receptor.
| estrogen receptor 1 (ER-alpha) | |
|---|---|
| Symbol | ESR1 |
| Alt. symbols | ER-α, NR3A1 |
| NCBI gene | 2099 |
| HGNC | 3467 |
How do estrogen receptors alter gene expression?
How does estrogen regulate gene expression? Estrogen can bind to classic estrogen receptors (ER), ERα and ERβ, which act as ligand-gated transcription factors that bind to DNA with the help of co-activators and co-repressors and alter DNA transcription (see [2] for more details).
What is the meaning of PPARs?
Abstract. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR 𝛼 is mainly expressed in the liver, where it activates fatty acid catabolism.
What is the gene for estrogen related receptor gamma?
Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.
What is role of ERRgamma gene in lupus?
Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis Esrrg is a novel lupus susceptibility gene that regulates the function and activation of CD4+ T cells through their mitochondrial metabolism.
How does estrogen-related receptor gamma regulate VLDL-TG secretion?
ERRgamma is a novel regulator of hepatic VLDL-TG secretion, which is mediated through the action on PLA2G12B. Estrogen-related receptor gamma mediates alcohol-induced hepatic lipogenesis by upregulating sterol regulatory element-binding protein-1c expression.
What is the role of estrogen-related receptor gamma in osteoarthritis?
Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA). MiR-204-5p inhibits myoblast differentiation by targeting MEF2C and ERRgamma.