What is myeloma maintenance?
Most myeloma patients will receive maintenance therapy as part of their treatment plan. Data has shown that maintenance therapy can extend progression free survival and overall survival after initial treatments which could include a variety of drug combinations or stem cell transplant.
What is Lenalidomide maintenance?
Lenalidomide is an immunomodulatory drug approved for maintenance treatment in newly diagnosed multiple myeloma, and it has been shown to improve progression-free survival (PFS) and, in several studies, overall survival.
Is Pomalidomide a chemotherapy?
Chemotherapy drugs, such as pomalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
What type of therapy is lenalidomide?
Lenalidomide works in several different ways and belongs to several different groups of drugs. It is a type of targeted therapy drug called an angiogenesis inhibitor and a cancer growth inhibitor. It is also a type of immunotherapy called an immune system modulator.
What does maintenance therapy for a transplantation patient entail?
Maintenance therapy refers to treatment given to patients after high-dose chemotherapy with autologous stem cell transplant (ASCT), while continuous therapy refers to treatment given to patients who do not go on to transplant after frontline therapy.
How is pomalidomide administered?
Pomalidomide should be administered on an empty stomach (at least 2 hours before or 2 hours after a meal). Missed doses may be administered if within 12 hours of the usual dosing time of pomalidomide.
How does pomalidomide work?
The drug, a capsule taken by mouth, belongs to a class of medications called immunomodulating agents. Pomalidomide does two things: first, it helps the bone marrow to produce normal blood cells, and second, it enhances the ability of immune cells to kill abnormal cells in the bone marrow.
What is the function of lenalidomide?
Lenalidomide is used to treat various types of cancers. It works by slowing or stopping the growth of cancer cells. It is also used to treat anemia in patients with certain blood/bone marrow disorders (myelodysplastic syndromes-MDS). Lenalidomide may lessen the need for blood transfusions.
What is the mechanism of action of lenalidomide?
Similar reductions in CDK2 activity have been demonstrated in myeloma derived cell lines, U266 and LP-1[34]. In contrast, the normal B cells obtained from healthy donors were immune from growth inhibition and did not show any upregulation of p21 expression after 3 days of lenalidomide treatment.
What is maintenance therapy psychology?
treatment or therapy designed to maintain patients in a stable condition and to promote gradual healing or prevent relapse.