What is hydrophilic lipophilic balance value?
Hydrophilic–lipophilic balance (HLB) is the balance of the size and strength of the hydrophilic and lipophilic moieties of a surfactant molecule. The HLB scale ranges from 0 to 20. In the range of 3.5 to 6.0, surfactants are more suitable for use in W/O emulsions.
What is the HLB of Span 80?
Span 80 has an HLB value of 4.3, which falls within the usual range of HLB 4–6 for water-in-oil (W/O) emulsifiers. Tween 80 has an HLB value of 15, within the range of HLB 8–18 for oil-in-water (O/W) emulsifiers.
Is span 80 hydrophilic?
Appearance of the emulsions solely stabilized by Tween 80 is shown in Fig. 1. Tween 80 is a hydrophilic nonionic surfactant with a hydrophile-lipophile balance value of 15.0 and a critical micelle concentration (cmc) value of 0.01 mM [22], [23].
How do you calculate Lipophile hydrophile balance?
Using the following equation: HLB desired = ( % surfactant A ) × ( HLB Surfactant A ) + ( % surfactant B ) × ( HLB Surfactant B . ) A blend of surfactant A, HLB = 7.8, and surfactant B, HLB = 13.4 produces a combination that is water soluble and contributes other desired properties.
What is the difference between hydrophilic and lipophilic?
Summary – Lipophilic vs Hydrophilic The key difference between lipophilic and hydrophilic is that lipophilic refers to the ability of a substance to dissolve in lipids or fats while hydrophilic refers to the ability of a substance to dissolve in water or other hydrophilic solvents.
Is lipophilic the same as hydrophobic?
Hydrophobic is often used interchangeably with lipophilic, “fat-loving”. However, the two terms are not synonymous. While hydrophobic substances are usually lipophilic, there are exceptions, such as the silicones and fluorocarbons.
Is Tween 80 water soluble?
Property: Tween-80 is light yellow to amber oily viscose liquid, non-toxic. It is easily soluble in water, soluble in ethanol, vegetable oil, ethyl acetate, methanol, and insoluble in mineral oil.
What is the difference between polysorbate 80 and Tween 80?
Tween 80 is also a polyethylene sorbitol ester, otherwise known as Polysorbate 80 or polyoxyethylene sorbitan monooleate. It has a molecular weight of 1.31 kDa and works well as a stabilizer and emulsifier, primarily in cosmetics, pharmaceuticals, and food products.
Is Tween 80 cationic surfactant?
Being a cationic surfactant, hexadecyl trimethylammonium bromide (CTAB) also efficiently dissociated insulin hexamers at concentrations of 1-5 mM. Tween 80, at 5 mM, neither significantly altered the alpha-chymotryptic degradation pattern nor enhanced the enteral absorption of insulin.
How do I choose a surfactant?
Surfactants have an HLB value – the higher the number the more hydrophilic (water soluble), the lower the number the more lipophilic (oil soluble). Oils and applications have an HLB requirement. Matching the HLB value with the HLB requirement will give good performance.
Is lipophilic hydrophilic?
Which is more hydrophilic spans or tweens?
Spans are sorbitan fatty acid esters having low HLB values ranging from 1.8 to 8.6. Tweens are polyoxyethylene derivatives of spans. So, they are more hydrophilic having V higher HLB values ranging from 9.6 to 16.7. \\ \\
What is the hydrophilic-lipophilic balance ( HLB ) scale?
Hydrophilic–lipophilic balance (HLB) is the balance of the size and strength of the hydrophilic and lipophilic moieties of a surfactant molecule. The HLB scale ranges from 0 to 20. In the range of 3.5 to 6.0, surfactants are more suitable for use in W/O emulsions.
What are the surfactants for hydrophilic lipophilic balance?
Surfactants between 8–16 include: proteins, phospholipids, potassium and sodium salts, and alginates (Kralova and Sjöblom, 2009 ). Nevertheless, there are limitations to the HLB concept.
What are the numbers for hydrophile-lipophile balance?
Hydrophile-Lipophile balance Hydrophile–Lipophile Balance (HLB) is a numerical system used to describe the relationship between the water-soluble and oil-soluble parts of a nonionic surfactant. HLB numbers range from 1 to 30 (perhaps higher).