What is dantrolene used for?
Dantrolene is used to treat spasticity (muscle stiffness and tightness) or muscle spasms associated with spinal cord injuries, stroke, multiple sclerosis, or cerebral palsy.
How long is Ryanodex good for?
Ryanodex (Eagle Pharmaceuticals, Woodcliff Lake, NJ, USA) is the newer hyperconcentrated form of dantrolene, is supplied as 250-mg vials (each mixed with 5 mL sterile water), has an approved shelf-life of 24 months, and costs $3,450 per year to stock.
How do you use Ryanodex?
Administer RYANODEX by intravenous push at a minimum dose of 1 mg/kg. If the physiologic and metabolic abnormalities of MH continue, administer additional intravenous boluses up to the maximum cumulative dosage of 10 mg/kg.
Who makes Ryanodex?
The drug manufacturer Eagle Pharma- ceuticals, Inc. is promoting Ryanodex as the first significant enhancement to MH treatment options in more than three decades.
How do you use dantrolene?
Oral Administration of Dantrium Capsules: Administer 4 to 8 mg/kg/day of oral Dantrium in three or four divided doses for 1 or 2 days prior to surgery, with the last dose being given with a minimum of water approximately 3 to 4 hours before scheduled surgery.
What is another name for dantrolene?
BRAND NAME(S): Dantrium.
How much dantrolene is in one vial of ryanodex?
One vial of RYANODEX® contains the same amount of dantrolene sodium as 12.5 vials of other approved formulations 5-7 Each vial of RYANODEX® contains 250 mg of dantrolene sodium and requires reconstitution with only 5 mL of sterile water for injection vs 60 mL per vial with other formulations1,5-7
What are the ingredients in ryanodex for injectable suspension?
Ryanodex ® (dantrolene sodium) for injectable suspension is a sterile lyophilized powder. Ryanodex is supplied in 20 mL vials containing 250 mg dantrolene sodium and the following inactive ingredients: 125 mg mannitol, 25 mg polysorbate 80, 4 mg povidone K12 and sufficient sodium hydroxide or hydrochloric acid for pH adjustment.
What are the indications and usage of ryanodex?
Indications and Usage for Ryanodex. Ryanodex ® is indicated for the: Treatment of malignant hyperthermia in conjunction with appropriate supportive measures [see Dosage and Administration (2.1)] Prevention of malignant hyperthermia in patients at high risk.
How long does it take to take 2.5 mg of ryanodex?
Time to administer 2.5 mg/kg loading dose of RYANODEX® for a 100 kg patient is 1 minute compared to >22 minutes for other approved formulations 1,4 * RYANODEX® requires fewer vials (depending on the patient) and less sterile water for injection volume compared to other dantrolene formulations 5-7