What does relaxation of detrusor muscle do?
The primary function of the detrusor muscle is to contract during urination to push the urine out of the bladder and into the urethra. The detrusor muscle will relax to allow the storage of urine in the urinary bladder.
What is the detrusor muscle innervated by?
| Detrusor muscle | |
|---|---|
| Nerve | Sympathetic – hypogastric n. (T10-L2) Parasympathetic – pelvic splanchnic nerves (S2-4) |
| Actions | Sympathetic relaxes, to store urine Parasympathetic contracts, to urinate |
| Identifiers | |
| Latin | musculus detrusor vesicae urinariae |
What is urinary bladder detrusor dysfunction?
Detrusor underactivity, or underactive bladder (UAB), is defined as a contraction of reduced strength and/or duration resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span. UAB can be observed in many neurologic conditions and myogenic failure.
What stimulates the detrusor muscle?
The parasympathetic nervous system stimulates the detrusor muscle to contract, causing the person to urinate. The sympathetic nervous system stimulates contraction of the internal urethral sphincter, causing the person to hold urine.
Which neurotransmitter causes detrusor contraction and relaxation?
The main neurotransmitter eliciting detrusor contraction is ACh, acting via M3 receptors; ATP, acting via P2X purinergic receptors may also elicit detrusor contraction in the setting of inflammation or other conditions associated with detrusor overactivity.
What causes detrusor instability?
It is defined as an involuntary phasic detrusor contraction of any pressure associated with symptoms of urge or leakage while the patient is attempting to inhibit micturition. The etiology is unknown but it has been associated with congenital causes, aging, stress incontinence, and bladder outlet obstruction.
What causes neurogenic detrusor overactivity?
Neurogenic detrusor overactivity (NDO) is a urodynamically measured bladder dysfunction caused by a lesion in the brain or spinal cord associated with a congenital condition (e.g., myelomeningocele), an acquired, stable condition (e.g., stroke, spinal cord injury [SCI]), or an acquired, progressive condition (e.g..
Which neurotransmitter produces detrusor contraction and bladder emptying?
In adults, the normal mechanism for activating contraction of the detrusor is the release of acetylcholine from parasympathetic nerves, stimulated by a spino bulbospinal micturition reflex,6 the main micturition reflex. Tension receptors in the detrusor activate afferents traveling in the pelvic nerves.