What diseases does HHV 8 cause?

What diseases does HHV 8 cause?

Recent findings: Diseases caused by HHV-8 infection include Kaposi sarcoma, multicentric Castleman disease (MCD), and primary effusion lymphoma (PEL), which occur primarily in patients with HIV infection. Kaposi sarcoma is the most common AIDS-associated malignancy worldwide.

Does HHV 8 causes Kaposi’s sarcoma?

Kaposi sarcoma (KS) is caused by infection with a virus called the Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). KSHV is in the same family as Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis (mono) and is linked to several types of cancer.

What virus is associated with lymphoma?

Lymphomas are perhaps the cancer type that is most closely associated with oncogenic viruses: infection with EBV, human T-lymphotropic virus 1 (HTLV-1), human immunodeficiency virus (HIV), Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, and hepatitis C virus have all been associated with lymphomagenesis.

What type of virus is HHV8?

The Human Herpesvirus-8 (HHV-8), also called Kaposi sarcoma Herpesvirus (KSHV), belongs to the family of DNA viruses Herpeseviridae. It causes Kaposi sarcoma (a vascular malignancy) and B cell lymphoproliferative diseases such as primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD).

Is NHL hereditary?

Non-Hodgkin lymphoma isn’t infectious and isn’t thought to run in families, although your risk may be slightly increased if a first-degree relative (such as a parent or sibling) has had lymphoma.

How do you know if you have HHV-8?

Clinical Manifestations Primary infection with HHV-8 in young, immunocompetent children may be asymptomatic or may present as a self-limited mononucleosis-like illness consisting of fever, mild upper respiratory symptoms, and a maculopapular rash. A similar presentation has been described in immunocompetent adults.

How can you get HHV-8?

HHV-8 is transmitted through saliva, but infection may also be acquired through sexual intercourse, blood transfusion, and organ transplantation [141]. HHV-8 causes Kaposi sarcoma (KS) and is linked with primary effusion lymphoma and multicentric Castleman disease (Table 8.4) [142].