How do you reconstitute remifentanil?
To reconstitute solution, add 1 mL of diluent per mg of remifentanil. Shake well to dissolve. When reconstituted as directed, the solution contains approximately 1 mg of remifentanil activity per 1 mL.
How is Diprivan administered?
Adult Patients In adults, anesthesia can be maintained by administering DIPRIVAN by infusion or intermittent IV bolus injection. The patient’s clinical response will determine the infusion rate or the amount and frequency of incremental injections.
Is remifentanil water soluble?
The chemical structure of remifentanil also allows the body to quickly metabolize the substance into nontoxic and water-soluble forms, thus minimizing risks for both hostages and hostage-takers.
What is reconstitution solution?
The process of adding a solvent or diluent to a medication in powdered form to dissolve it and form a solution is referred to as reconstitution. Reconstitution is necessary for medications that come in powdered form before they can be measured and administered.
How do you dilute propofol?
The maximum dilution must not exceed 1 part of Propofol with 4 parts of glucose 50 mg/ml (5%) solution for injection, sodium chloride 9 mg/ml (0.9%) solution for injection or sodium chloride 1.8 mg/ml (0.18%) and glucose 40 mg/ml (4%) solution for injection (minimum concentration 2 mg propofol/ml).
How much Propofol is used for colonoscopy?
This was similar to the nurse-administered propofol sedation (NAPS) technique described by Rex et al (3), who noted that the dose of propofol required to initiate the colonoscopy may vary from 30 to >200 mg. If the patient seemed to experience discomfort during the procedure, a 10- to 20-mg bolus was delivered.
What is the action of remifentanil?
Remifentanil is a new synthetic opioid with direct action on mu-opioid receptors. It has a rapid onset and short latency to peak effect. It is rapidly inactivated by esterases in both blood and tissues, resulting in a very short duration of action.
Is remifentanil an acid or base?
Remifentanil is a weak base with a Pka of 7.07. This chemical property makes it a highly protein-bound drug, approximately 70%, which two-thirds binds to alpha-1 -acid glycoprotein.