What is MYC gene rearrangement?
Purpose: MYC rearrangement (MYC-R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many studies. The impact of MYC-R on prognosis may be influenced by the MYC partner gene (immunoglobulin [IG] or a non-IG gene).
What type of mutation is Burkitt’s lymphoma?
Burkitt lymphoma results from chromosome translocations that involve the Myc gene. A chromosome translocation means that a chromosome is broken, which allows it to associate with parts of other chromosomes. The classic chromosome translocation in Burkitt lymophoma involves chromosome 8, the site of the Myc gene.
What are 3 alterations in the MYC gene that have been observed in cancers and that result in MYC activation?
Such alterations include (1) point mutations in the MYC coding region that appear to increase MYC protein stability and activity as secondary events to translocations in lymphoma (Bahram et al., 2000, Hemann et al., 2005); (2) mutation or rare amplification of distal enhancers (Sur et al., 2012, Zhang et al., 2016); …
What is MYC in lymphoma?
MYC is a potent oncogene initially identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior.
Is MYC a tumor suppressor gene?
The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation.
What does MYC gene stand for?
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.
How does MYC cause Burkitt lymphoma?
All forms of Burkitt lymphoma are associated with a translocation of the MYC gene on chromosome 8 into one of the three immunoglobulin loci, resulting in MYC protein overexpression and uncontrolled cell growth.
What does the MYC gene do?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
What is MYC biology?
c-Myc, v-myc. NCBI gene. 4609. HGNC. 7553.
What type of gene is myc?
Where is myc gene?
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).
What cancers is MYC associated with?
MYC is documented to be involved broadly in many cancers, in which its expression is estimated to be elevated or deregulated in up to 70% of human cancers. High levels of MYC expression have been linked to aggressive human prostate cancer and triple negative breast cancer (Gurel et al., 2008; Palaskas et al., 2011).
Is the Myc translocation a hallmark of Burkitt lymphoma?
Translocation (a type of rearrangement) of a gene called MYC is a hallmark of Burkitt lymphoma, making this an important finding for diagnosis. In adults, Burkitt lymphoma is often indistinguishable from diffuse large B-cell lymphoma (DLBCL)–another aggressive B-cell lymphoma.
How does Burkitt lymphoma spread to the CNS?
Burkitt lymphoma may spread to the central nervous system (CNS). Translocation (a type of rearrangement) of a gene called MYC is a hallmark of Burkitt lymphoma, making this an important finding for diagnosis. In adults, Burkitt lymphoma is often indistinguishable from diffuse large B-cell lymphoma (DLBCL)–another aggressive B-cell lymphoma.
How is a chromosome broken in Burkitt lymphoma?
A chromosome translocation means that a chromosome is broken, which allows it to associate with parts of other chromosomes. The classic chromosome translocation in Burkitt lymophoma involves chromosome 8, the site of the Myc gene.
Is there a difference between Burkitt lymphoma and DLBCL?
In adults, Burkitt lymphoma is often indistinguishable from diffuse large B-cell lymphoma (DLBCL)–another aggressive B-cell lymphoma. Accurate diagnosis of Burkitt lymphoma is critical because Burkitt lymphoma and DLBCL are treated differently.