Can Herceptin be used for ovarian cancer?
Background. Early studies have demonstrated comparable levels of HER2/ErbB2 expression in both breast and ovarian cancer. Trastuzumab (Herceptin), a therapeutic monoclonal antibody directed against HER2, is FDA-approved for the treatment of both early and late stage breast cancer.
Is Herceptin given with chemo?
Herceptin is approved, in combination with chemotherapy (cisplatin and either capecitabine or 5-fluorouracil), for the treatment of HER2-positive metastatic cancer of the stomach or gastroesophageal junction (where the esophagus meets the stomach) in patients who have not received prior treatment for their metastatic …
What is the difference between Herceptin and Herceptin Hylecta?
Herceptin contains one active ingredient, trastuzumab, and is given as an intravenous (IV) infusion slowly into a vein. Herceptin Hylecta contains two active ingredients, trastuzumab and hyaluronidase-oysk, and is given as a subcutaneous injection, which is an injection that goes under the skin.
Why is chemotherapy given in combination?
The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.
Can ovarian cancer be HER2 positive?
HER2 overexpression/amplification has been reported in ovarian cancer, but the exact percentage of HER2-positive tumors varies widely in the literature (between 8% and 66%) and is associated with poor clinical outcome.
Is Herceptin Hylecta better than Herceptin?
The approval is based on results from the HannaH trial and the SafeHER studies showing that Herceptin Hylecta is as effective and as safe as Herceptin.
How do you give Phesgo injections?
PHESGO is administered by slowly injecting it just under the skin of the thigh. At each appointment, the injection alternates between the left and right thigh.
What are the side effects of combination therapy?
The most common side-effects of combined chemohormonal therapy were gastro-intestinal (nausea, vomiting, rarely diarrhoea) in 43 patients (57.3%), followed by alopecia in 23 patients (30.6%), myelosuppression in 12 patients (16%), extravasation and thrombophlebitis in 7 patients (9.3%), and mucositis and oral erythema …
What are the benefits of combination therapy?
Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.
How does Herceptin work to treat breast cancer?
Herceptin works by attaching itself to the HER2 receptors on the surface of breast cancer cells and blocking them from receiving growth signals. By blocking the signals, Herceptin can slow or stop the growth of the breast cancer. Herceptin is an example of an immune targeted therapy.
Can a woman get pregnant while taking herceptin?
It’s important to know that women who are pregnant or planning to get pregnant should not take Herceptin. Herceptin can harm the developing fetus. If there is any chance you can become pregnant, you must use effective birth control while you’re taking Herceptin and for at least 7 months after your last dose.
What should I do before starting Herceptin therapy?
Before starting Herceptin therapy, you should have an echocardiogram or a MUGA (multigated blood-pool imaging) scan to check how well your heart is functioning. An echocardiogram uses sound waves to take detailed pictures of the heart as it pumps blood.
What happens to your heart when you take Herceptin?
Your doctor will continue to monitor your heart function while you are receiving Herceptin, as well as after you complete treatment. Herceptin may cause inflammation of the lungs, which can be life-threatening. Symptoms include trouble breathing, cough, tiredness, and fluid in the lungs.