Does Akt have PH domain?
Akt is a 480 amino acid protein that contains an N-terminal PH (pleckstrin homology) domain followed by a catalytic (kinase) domain and culminates in a regulatory C-terminal disordered tail (C-tail) (Figure 1A).
What does the PH domain do?
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.
What type of enzyme is Akt?
protein kinase
AKT/PKB is a phosphoinositide-dependent serine/threonine protein kinase that plays a critical role in the signal transduction of receptors.
Why is protein kinase B called Akt?
PKB/AKT is a serine/threonine protein kinase that was originally discovered as a cellular homolog of v-AKT, a retroviral oncogene (Manning and Toker, 2017; Staal, 1987). It has been termed as PKB because of its structural similarities with protein kinase A and protein kinase C (Coffer and Woodgett, 1991).
What does PDZ domain stand for?
PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). …
Is Akt an oncogene?
AKT was first discovered in the 1970s as an oncogene transduced by the transforming retrovirus (AKT‐8), which was isolated from an AKR mouse thymoma cell line and first molecularly cloned in 1991.
What gene encodes for Akt?
RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as “Akt/PKB”.
Is Akt a protein kinase B?
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKBalpha (Akt1), PKBbeta (Akt2), and PKBgamma (Akt3). PKB/Akt is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components.
What is WW in biology?
The WW domain, (also known as the rsp5-domain or WWP repeating motif) is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins.
Does casein have a SH2 domain?
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins….SH2 domain.
| Identifiers | |
|---|---|
| Pfam | PF00017 |
| InterPro | IPR000980 |
| SMART | SH2 |
| PROSITE | PDOC50001 |