What causes osteitis deformans?
Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease. Some scientists believe Paget’s disease of bone is related to a viral infection in your bone cells, but this theory is controversial.
Can Paget’s disease cause neuropathy?
Nerve problems Possible signs of this can include: pain travelling from the spine down into your legs (sciatica) pain travelling from your neck into your arms and chest. numbness or tingling in the affected limbs (peripheral neuropathy)
Does Paget’s disease cause hypocalcemia?
QUICK SUMMARY: Mineralization defects and hypocalcemia with secondary hyperparathyroidism have been described in patients with Paget’s disease of bone treated with bisphosphonates. Secondary hyperparathyroidism may be a potentially detrimental condition for patients with Paget’s disease of bone.
What is also known as osteitis deformans?
A chronic condition in which both the breakdown and regrowth of bone are increased. Osteitis deformans occurs most frequently in the pelvic and leg bones, skull, and lower spine. It is most common in older individuals, and may lead to bone pain, deformities, and fractures. Also called Paget disease of bone.
What are the symptoms of osteomalacia?
As osteomalacia progresses, you might develop bone pain and muscle weakness. The dull, aching pain associated with osteomalacia most commonly affects the lower back, pelvis, hips, legs and ribs. The pain might be worse at night or when you put pressure on the bones. The pain is rarely relieved completely by rest.
Why does ALP increase in osteomalacia?
Increased serum alkaline phosphatase or bone specific alkaline phosphatase activity is classically associated with osteomalacia due to vitamin D deficiency but is not an early or reliable clue because some patients may have normal or only borderline elevated levels.
Why does Paget’s disease cause hypercalcemia?
Too much calcium in the blood In rare cases, the increased cycle of bone renewal in Paget’s disease of bone can result in calcium building up in the blood. This is known as hypercalcaemia. It usually only occurs in people who have been confined to bed after an operation or a fracture.
What is definition of osteitis?
Osteitis: Inflammation of the bone.
What causes sore pubic bone?
Trauma or accident. Injury to the pelvic region may cause the inflammation and bone stress that is present in osteitis pubis. Rheumatological disorders. Conditions that cause inflammation throughout the body may result in osteitis pubis.