What is the dosing for tenecteplase?
TNKase® (Tenecteplase) is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight….Dose Information Table.
| Patient Weight (kg) | TNKase (mg) | Volume TNKase* to be administered (mL) |
|---|---|---|
| < 60 | 30 | 6 |
| ≥ 60 to < 70 | 35 | 7 |
| ≥ 70 to < 80 | 40 | 8 |
| ≥ 80 to < 90 | 45 | 9 |
How do you administer tenecteplase?
Intravenous injection: Administer via a dedicated IV line in which no other medications are being simultaneously injected or infused. Reconstituted tenecteplase should be administered as a single IV bolus over 5 seconds. Precipitation may occur when tenecteplase is administered in an IV line containing dextrose.
How do you give a tenecteplase to a stroke?
Current clinical practice guidelines for stroke include intravenous tenecteplase at either dose as a second-tier option, with the 0.25 mg/kg dose recommended for large vessel occlusions, based on a phase 2 trial that demonstrated superior recanalization and improved 3-month outcome relative to alteplase.
What is the difference between alteplase and tenecteplase?
Background. Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer activity than alteplase, is given as a bolus and may increase the incidence of vascular reperfusion.
What is the antidote for tenecteplase?
Thrombolytic agents convert plasminogen to plasmin, which degrades fibrin at the site of thrombus formation. Antifibrinolytics such as aminocaproic acid (Amicar) seem to be a logical antidote to fibrinolytic therapy and have been proposed as an aggressive measure for limiting intracranial bleeding.
Who manufactures tenecteplase?
Genentech: TNKase® (tenecteplase) – Information for Patients.
What is tenecteplase FDA approved for?
TNKase® (Tenecteplase) is indicated for use in the reduction of mortality associated with acute myocardial infarction (AMI). Treatment should be initiated as soon as possible after the onset of AMI symptoms (see CLINICAL STUDIES).
How long does it take for tenecteplase to work?
Tenecteplase can be given by a single bolus injection. This will improve the blood flow through the infarct-related artery in most patients within 90 minutes. The elimination is biphasic with a terminal half-life of approximately two hours. Clearance is by hepatic metabolism.
Why is tPA not given after 3 hours?
Most of them are ineligible because they come to the hospital after the three-hour time window.” The timing of treatment is important, because giving a strong blood thinner like tPA during a stroke can cause bleeding inside the brain.
Is tPA used for ischemic stroke?
FDA approves tPA for the treatment of acute ischemic stroke.
How many mg of Tenecteplase is in TNKase?
Each vial of TNKase nominally contains 52.5 mg Tenecteplase, 0.55 g L-Arginine, 0.17 g Phosphoric Acid, and 4.3 mg polysorbate 20, which includes a 5% overfill. Each vial will deliver 50 mg of Tenecteplase. Return to Table of Contents CLINICAL PHARMACOLOGY
Can you take tenecteplase in an IV line?
It is recommended that standard antiarrhythmia therapy for bradycardia and/or ventricular irritability be available during tenecteplase therapy. Precipitation may occur when tenecteplase is administered in an IV line containing dextrose.
How old do you have to be to take tenecteplase?
In general, tenecteplase should be used cautiously if at all in clinical situations associated with an increased risk of bleeding (i.e., major surgery, recent history of bleeding or trauma). Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
What is the plasma clearance rate for tenecteplase?
In 99 of 104 patients treated with Tenecteplase, mean plasma clearance ranged from 99 to 119 mL/min. The initial volume of distribution is weight related and approximates plasma volume. Liver metabolism is the major clearance mechanism for Tenecteplase. Return to Table of Contents