Can osteomalacia be Tumour induced?
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23).
What is tumor-induced osteomalacia?
Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness. The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23).
What causes Tio?
TIO is typically caused by slow-growing tumors, which produce excess amounts of FGF23, a protein that regulates phosphate and vitamin D, both of which are important for bone health.
Is osteomalacia a cancer?
These tumors most commonly occur in the skin, muscles, or bones of the extremities or in the paranasal sinuses around the head. Most of these tumors are benign, meaning they are not associated with cancer . Oncogenic osteomalacia can occur in children or adults.
What is Tio in medical terms?
Abstract. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness.
What is Xlh?
X-linked hypophosphatemia (XLH) is an inherited disorder characterized by low levels of phosphate in the blood. Phosphate levels are low because phosphate is abnormally processed in the kidneys, which causes a loss of phosphate in the urine (phosphate wasting) and leads to soft, weak bones (rickets).
What is Tio disease?
Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by bone pain, muscle weakness and fractures associated with persistent hypophosphatemia due to renal phosphate wasting, inappropriately normal or low 1,25(OH)2D and elevated or inappropriately normal …
What are examples of mesenchymal tissue?
Mesenchymal Stem Cells In the case of MSCs, the lineage-committed cells can generate a variety of specialized mesenchymal tissues including bone, cartilage, muscle, marrow stroma, tendon, ligament, fat, and a variety of other connective tissues (Caplan, 1994).